Purpose: To investigate differential up-regulation of erythropoietin and its receptor in benign and malignant prostatic tissue.
Materials and methods: An immunohistochemical analysis of EPO and EPOR expression was performed on 30 cases of prostate carcinoma (PCa) with 16 high-grade prostate intraepithelial neoplasia (PIN), 50 cases of benign prostatic hyperplasia (BPH) lesions, and 30 normal prostatic tissue samples as control.
Results: Over-expression of EPOR was only shown in PCa and high-grade PIN tissue but over-expression of EPO was also shown in BPH tissue. There was significant relationship between EPO and EPOR score in BPH, high-grade PIN, and PCa but no association between EPOR or EPO score and Gleason score in PCa.
Conclusions: Up-regulation of EPOR has a more important role in comparison with EPO in prostate carcinogenesis. Differential over-expression of EPOR and EPO in benign and malignant prostatic tissue is ascribed to different mechanisms involved in up-regulation between EPO and EPOR.
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