Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi

J Nat Prod. 2009 Jan;72(1):117-24. doi: 10.1021/np800460b.

Abstract

Twelve new xanthones (1-12), a pair of new natural products (13 and 14), and 18 known related compounds were isolated from the resin of Garcinia hanburyi. The structures of 1-14 were elucidated by detailed spectroscopic analyses. A cytotoxic assay of the isolated compounds revealed that, with the exception of 2, these compounds were active against the HeLa tumor cell line.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • China
  • Drug Screening Assays, Antitumor
  • Garcinia / chemistry*
  • HeLa Cells
  • Humans
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Resins, Plant / chemistry
  • Xanthones / chemistry
  • Xanthones / isolation & purification*
  • Xanthones / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Resins, Plant
  • Xanthones