Theileria apicoplast as a target for chemotherapy

Antimicrob Agents Chemother. 2009 Mar;53(3):1213-7. doi: 10.1128/AAC.00126-08. Epub 2008 Dec 15.

Abstract

Theileria parasites cause severe bovine disease and death in a large part of the world. These apicomplexan parasites possess a relic plastid (apicoplast), whose metabolic pathways include several promising drug targets. Putative inhibitors of these targets were screened, and we identified antiproliferative compounds that merit further characterization.

MeSH terms

  • Animals
  • Antiprotozoal Agents / pharmacology*
  • Cattle
  • Drug Delivery Systems
  • Inhibitory Concentration 50
  • Models, Biological
  • Plastids / drug effects
  • Plastids / metabolism*
  • Theileria / drug effects*
  • Theileria / metabolism*
  • Theileriasis / drug therapy*
  • Theileriasis / metabolism
  • Theileriasis / parasitology

Substances

  • Antiprotozoal Agents