Osteoporosis associated with non-familial acro-osteolysis successful treatment with an anti-resorptive agent

J Clin Rheumatol. 1999 Dec;5(6):346-8. doi: 10.1097/00124743-199912000-00009.

Abstract

The syndrome non-familial acro-osteolysis features bone reabsorption of the digits in association with short stature. Osteoporosis is common in this disorder, but no successful treatment has been previously reported. We report a case of non-familial acro-osteolysis complicated by multiple fractures in which treatment with antiresorptive therapy improved both biochemical markers of bone turnover and bone mineral density but had no effect on the acro-osteolysis.