Putting a KAP on transcription and stress

Mark D Alter; Rene Hen

doi:10.1016/j.neuron.2008.12.002

Putting a KAP on transcription and stress

Neuron. 2008 Dec 10;60(5):733-5. doi: 10.1016/j.neuron.2008.12.002.

Authors

Mark D Alter¹, Rene Hen

Affiliation

¹ Department of Psychiatry, Columbia University, New York, NY 10032, USA.

PMID: 19081366
DOI: 10.1016/j.neuron.2008.12.002

Abstract

Chromatin regulation plays an important role in brain development and the generation of phenotypic diversity. In this issue of Neuron, Jakobsson et al. find that disruption in neurons of KAP1, a key component of transcriptional repressor complexes in the brain, results in increased anxiety-like behavior and sensitivity to stress.

Publication types

Review
Comment

MeSH terms

Animals
Brain / metabolism
Nuclear Proteins / genetics
Nuclear Proteins / physiology*
Repressor Proteins / genetics
Repressor Proteins / physiology*
Stress, Psychological / genetics
Stress, Psychological / metabolism*
Stress, Psychological / pathology
Transcription, Genetic / physiology*
Tripartite Motif-Containing Protein 28

Substances

Nuclear Proteins
Repressor Proteins
Trim28 protein, mouse
Tripartite Motif-Containing Protein 28