Abstract
The present study describes a novel non-radioactive methodology for in vivo non-invasive, real-time imaging of blood-brain barrier (BBB) permeability for conventional drugs, using nitroxyl radicals as spin-labels and magnetic resonance imaging (MRI).
MeSH terms
-
Animals
-
Antineoplastic Agents
-
Antioxidants
-
Autoradiography
-
Blood-Brain Barrier / anatomy & histology*
-
Blood-Brain Barrier / drug effects*
-
Cyclic N-Oxides
-
Drug Evaluation, Preclinical
-
Free Radicals / chemistry*
-
Indicators and Reagents
-
Lomustine / analogs & derivatives
-
Magnetic Resonance Imaging / methods*
-
Mice
-
Nitrogen Compounds / chemistry*
-
Nitrogen Compounds / toxicity
-
Nitrogen Oxides / chemistry*
-
Permeability / drug effects
-
Pharmaceutical Preparations / metabolism*
-
Positron-Emission Tomography
-
Spin Labels / chemical synthesis*
Substances
-
Antineoplastic Agents
-
Antioxidants
-
Cyclic N-Oxides
-
Free Radicals
-
Indicators and Reagents
-
Nitrogen Compounds
-
Nitrogen Oxides
-
Pharmaceutical Preparations
-
Spin Labels
-
Lomustine
-
nitroxyl
-
TEMPO