Evolution of tertiary carbinamine BACE-1 inhibitors: Abeta reduction in rhesus CSF upon oral dosing

ChemMedChem. 2009 Jan;4(1):37-40. doi: 10.1002/cmdc.200800308.
No abstract available

MeSH terms

  • Administration, Oral
  • Amines / administration & dosage
  • Amines / chemistry*
  • Amines / pharmacology
  • Amyloid Precursor Protein Secretases / antagonists & inhibitors*
  • Amyloid Precursor Protein Secretases / chemistry
  • Amyloid Precursor Protein Secretases / metabolism
  • Amyloid beta-Peptides / cerebrospinal fluid*
  • Animals
  • Blood-Brain Barrier
  • Crystallography, X-Ray
  • Haplorhini
  • Inhibitory Concentration 50
  • Macaca mulatta
  • Molecular Conformation
  • Peptide Fragments / cerebrospinal fluid*
  • Protease Inhibitors / administration & dosage
  • Protease Inhibitors / chemistry*
  • Protease Inhibitors / pharmacology
  • Structure-Activity Relationship

Substances

  • Amines
  • Amyloid beta-Peptides
  • Peptide Fragments
  • Protease Inhibitors
  • amyloid beta-protein (40-42)
  • Amyloid Precursor Protein Secretases