Abstract
The screening for active compounds against malignant pleural mesothelioma (MPM) cells produced by Streptomyces sp. AK-AB27 resulted in the isolation of two compounds with a dodecahydrodibenzo[b,d]furan skeleton named JBIR-23 (1) and -24 (2). Their structures were established on the basis of extensive NMR and MS analyses. Compounds 1 and 2 exhibited cytotoxic effects against several MPM cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / therapeutic use
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Benzofurans / chemistry
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Benzofurans / isolation & purification*
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Benzofurans / pharmacology*
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Benzofurans / therapeutic use
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Cell Line, Tumor
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Drug Evaluation, Preclinical
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Humans
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Mesothelioma / drug therapy
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Streptomyces / chemistry*
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Streptomyces / classification
Substances
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Antineoplastic Agents
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Benzofurans
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JBIR-23
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JBIR-24