Abstract
The administration of Li2CO3 to female LACA mice for three consecutive days before or after 4Gy whole body gamma-irradiation appeared to have both preventive and therapeutic effects on radiation-induced leucopenia, especially on the depression of CFU-GM. It is effective in small dosage, short course, and even when given 24 hours after irradiation.
MeSH terms
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Animals
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Colony-Forming Units Assay
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Female
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Hematopoiesis / drug effects
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Leukopenia / drug therapy
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Leukopenia / prevention & control*
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Lithium / pharmacology
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Lithium / therapeutic use*
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Lithium Carbonate
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Male
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Mice
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Radiation Injuries, Experimental / drug therapy
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Radiation Injuries, Experimental / prevention & control*
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Whole-Body Irradiation
Substances
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Lithium Carbonate
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Lithium