Abstract
Controlled studies on the immunopathogenesis of mucosal candidiasis in HIV infection have been hampered by the lack of a relevant animal model. We have previously reported that oral Candida infection in CD4C/HIV transgenic mice expressing gene products of HIV-1 in immune cells and developing an AIDS-like disease closely mimics oropharyngeal candidiasis in human HIV infection. The role of defective dendritic cells and CD4+ T cells in impaired induction of protective immunity and in the phenotype of chronic oral carriage of C. albicans can now be investigated under controlled conditions in these transgenic mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS-Related Opportunistic Infections / etiology*
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AIDS-Related Opportunistic Infections / immunology
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Animals
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Base Sequence
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CD4-Positive T-Lymphocytes / immunology
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Candida albicans / immunology*
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Candida albicans / pathogenicity*
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Candidiasis, Oral / etiology*
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Candidiasis, Oral / immunology
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Cytokines / genetics
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Cytokines / metabolism
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DNA Primers / genetics
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Dendritic Cells / immunology
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Disease Models, Animal
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Female
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Flow Cytometry
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HIV-1 / genetics*
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HIV-1 / pathogenicity*
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Humans
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Male
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Mice
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Mice, Transgenic
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Mouth Mucosa / immunology*
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Mouth Mucosa / microbiology*