Abstract
A receiver operating curve analysis was performed to assess the predictive value of the urinary cystatin C to urinary creatinine ratio for the renal monitoring of tenofovir. Urinary cystatin C to urinary creatinine ratio was measured in 37 samples from patients referred for suspected tenofovir-induced Fanconi syndrome. The best threshold (14 microg/mmol) was associated with sensitivity, 90.9%; specificity, 88.5%; positive predictive value, 76.9%; and negative predictive value, 95.8%. Urinary cystatin C to urinary creatinine ratio allows to rule out a Fanconi syndrome in most cases; thus, it should be used for the safety follow-up of nucleotide reverse transcriptase inhibitor-treated patients.
Publication types
-
Evaluation Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adenine / adverse effects
-
Adenine / analogs & derivatives*
-
Adenine / therapeutic use
-
Anti-HIV Agents / adverse effects*
-
Anti-HIV Agents / therapeutic use
-
Biomarkers / urine
-
Creatinine / urine
-
Cystatin C / urine*
-
Fanconi Syndrome / chemically induced*
-
Fanconi Syndrome / diagnosis*
-
HIV Infections / drug therapy
-
Humans
-
Hypophosphatemia / chemically induced
-
Hypophosphatemia / diagnosis
-
Organophosphonates / adverse effects*
-
Organophosphonates / therapeutic use
-
Retrospective Studies
-
Sensitivity and Specificity
-
Tenofovir
Substances
-
Anti-HIV Agents
-
Biomarkers
-
Cystatin C
-
Organophosphonates
-
Tenofovir
-
Creatinine
-
Adenine