Alternative splicing of CD45: the tip of the iceberg

Immunity. 2008 Dec 19;29(6):839-41. doi: 10.1016/j.immuni.2008.12.005.

Abstract

Mechanisms underlying the regulated splicing of CD45 RNA have been long-standing puzzles. In this issue of Immunity, Wu et al. (2008) identify hnRNPLL as a critical regulator of both signal-induced exon skipping in CD45 and global alternative-transcript expression in memory T cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Alternative Splicing / genetics*
  • Animals
  • Exons / genetics*
  • Humans
  • Leukocyte Common Antigens / genetics*
  • Mice
  • Protein Isoforms / genetics
  • T-Lymphocytes / metabolism*

Substances

  • Protein Isoforms
  • Leukocyte Common Antigens