Memory B and T cells

Annu Rev Immunol. 1991:9:193-217. doi: 10.1146/annurev.iy.09.040191.001205.

Abstract

Three remarkable and unique features of the immune system are specificity, diversity, and memory. Immunological memory involves both T and B cells and results in a secondary antibody response that is faster, of higher affinity, and results in the secretion of non-IgM isotypes of Ig. In this review we discuss the properties of memory T and B cells, their specific receptors, and the events which occur both in the nucleus and on the cell surface during generation and activation of these cells. Although memory T and B cells use different mechanisms to elaborate memory, there are a number of interesting analogies: lymphokines vs antibodies and affinity maturation of B cell antigen receptors vs upregulation of adhesion molecules on T cells. Finally, we discuss the importance of these cells in health and disease and suggest what impact additional information about these cells might have on the manipulation of the immune response.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antibody Affinity
  • Antigens, Differentiation
  • B-Lymphocytes / immunology*
  • Cell Survival
  • Humans
  • Immunologic Memory*
  • T-Lymphocytes / immunology*

Substances

  • Antigens, Differentiation