Abstract
The aerobic respiratory chain of Escherichia coli has two terminal quinol oxidases: cytochrome bo and cytochrome bd. Cytochrome bd was thought to function solely to facilitate micro-aerobic respiration. However, it has recently been shown to be overexpressed under conditions of nitric oxide (NO) stress; we show here that cytochrome bd is crucial for protecting E. coli cells from NO-induced growth inhibition by virtue of its fast NO dissociation rate.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cytochrome b Group
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Cytochromes / metabolism*
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Electron Transport Chain Complex Proteins / metabolism*
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Escherichia coli / enzymology
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Escherichia coli / growth & development
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Escherichia coli / metabolism*
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Escherichia coli Proteins / metabolism*
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Nitric Oxide / metabolism*
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Oxidoreductases / metabolism*
Substances
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Cytochrome b Group
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Cytochromes
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Electron Transport Chain Complex Proteins
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Escherichia coli Proteins
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Nitric Oxide
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Oxidoreductases
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cytochrome bd terminal oxidase complex, E coli
Associated data
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PubChem-Substance/56412693
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PubChem-Substance/56412694
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PubChem-Substance/56412695
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PubChem-Substance/56412696
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PubChem-Substance/56412697
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PubChem-Substance/56412698