The influence of steroid therapy and recombinant human erythropoietin on the growth of children with renal disease

Pediatr Nephrol. 1991 Jul;5(4):556-8. doi: 10.1007/BF01453701.

Abstract

Long-term steroid therapy has a depressant effect on hypothalamo-pituitary pulsatile secretion of growth hormone (GH), and this results in an attenuated pubertal growth spurt. Oxandrolone and recombinant human GH improve growth rates in children taking long-term steroid therapy for renal disease, but there are potential side effects. Treatment with recombinant human erythropoietin improved the growth of three prepubertal, but not three pubertal haemodialysis patients.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Anemia / drug therapy
  • Child
  • Child, Preschool
  • Erythropoietin / therapeutic use*
  • Growth / drug effects*
  • Growth Disorders / drug therapy*
  • Growth Disorders / physiopathology
  • Growth Hormone / metabolism
  • Growth Hormone / therapeutic use
  • Humans
  • Kidney Failure, Chronic / physiopathology*
  • Kidney Transplantation
  • Oxandrolone / therapeutic use
  • Recombinant Proteins / therapeutic use
  • Renal Dialysis
  • Steroids / adverse effects*

Substances

  • Recombinant Proteins
  • Steroids
  • Erythropoietin
  • Oxandrolone
  • Growth Hormone