Homotyrosine-containing cyanopeptolins 880 and 960 and anabaenopeptins 908 and 915 from Planktothrix agardhii CYA 126/8

J Nat Prod. 2009 Jan;72(1):172-6. doi: 10.1021/np800557m.

Abstract

Two homotyrosine-bearing cyanopeptolins are described from Planktothrix agardhii CYA 126/8. The compounds feature a common homotyrosine-containing cyclohexadepsipeptide and differ by sulfation of an exocyclically located 2-O-methyl-d-glyceric acid residue. In addition we describe two anabaenopeptins, which contain two homotyrosine residues, one of which is N-methylated. The anabaenopeptins have a common cyclopentapeptide portion and differ in the amino acid linked to it via an ureido bond, arginine and tyrosine, respectively.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cyanobacteria / chemistry*
  • Depsipeptides
  • Hawaii
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Peptides, Cyclic / chemistry*
  • Peptides, Cyclic / isolation & purification*
  • Tyrosine / analogs & derivatives
  • Tyrosine / chemistry

Substances

  • Depsipeptides
  • Peptides, Cyclic
  • anabaenopeptin 908
  • anabaenopeptin 915
  • cyanopeptolin 880
  • cyanopeptolin 960
  • Tyrosine