Abstract
It is believed that beta-amyloid aggregation is an important event in the development of Alzheimer's disease. In the course of our studies to identify beta-amyloid aggregation inhibitors, a series of N-phenyl anthranilic acid analogs were synthesized and studied for beta-amyloid inhibition activity. The synthesis, structure-activity relationship, and in vivo activity of these analogs are discussed.
MeSH terms
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Alzheimer Disease
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Amyloid / chemistry*
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Animals
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Chemistry, Pharmaceutical / methods*
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Disease Models, Animal
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Drug Design
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Enzyme Inhibitors / pharmacology
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Fenamates / chemical synthesis
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Fenamates / chemistry*
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Humans
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Mice
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Microscopy, Atomic Force
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Models, Chemical
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Molecular Structure
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Peptides / chemistry
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Structure-Activity Relationship
Substances
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Amyloid
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Enzyme Inhibitors
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Fenamates
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Peptides