[New development in bisphosphonate treatment. Bisphosphonates for the treatment of glucocorticoid-induced osteoporosis]

Satoshi Soen

[New development in bisphosphonate treatment. Bisphosphonates for the treatment of glucocorticoid-induced osteoporosis]

Clin Calcium. 2009 Jan;19(1):44-53.

[Article in Japanese]

Author

Satoshi Soen¹

Affiliation

¹ Kinki University School of Medicine, Nara Hospital, Department of Orthopaedic Surgery and Rheumatology, Japan.

PMID: 19122264

Abstract

Only bisphosphonates were shown to decrease the risk of vertebral fractures in patients taking glucocorticoids. Relative risk at 1 year treatment with bisphosphonates for incident vertebral fractures and non-vertebral fractures were 0.46 (95% confidence interval : 0.28 - 0.77) and 0.77 (95% confidence interval : 0.39 - 1.51) , respectively. Two years extension of the alendronate trial showed that relative risk for incident vertebral fractures was 0.10 (95% confidence interval : 0.01 - 0.90) .

Publication types

English Abstract
Review

MeSH terms

Bone Density Conservation Agents / therapeutic use*
Diphosphonates / therapeutic use*
Fractures, Spontaneous / etiology
Fractures, Spontaneous / prevention & control
Glucocorticoids / adverse effects*
Humans
Meta-Analysis as Topic
Osteoporosis / chemically induced*
Osteoporosis / complications
Osteoporosis / drug therapy*
Randomized Controlled Trials as Topic
Risk
Spinal Fractures / etiology
Spinal Fractures / prevention & control

Substances

Bone Density Conservation Agents
Diphosphonates
Glucocorticoids