Effect of additives on chemoselectivity and diastereoselectivity in the catalytic epoxidation of chiral allylic alcohols with hydrogen peroxide and binuclear manganese complexes

J Org Chem. 2009 Feb 6;74(3):1135-40. doi: 10.1021/jo801974e.

Abstract

The catalytic oxidations of chiral allylic alcohols 2 by manganese complexes of the cyclic triamine 1,4,7-trimethyl-1,4,7-triazacyclononane (tmtacn) 1 and hydrogen peroxide as oxygen donor in the presence of co-catalyst are investigated to understand the factors that affect the catalyst selectivity. Chemoselectivity and diastereoselectivity of catalyst 1 are significantly affected by the structure of the allylic alcohol and the nature and amount of co-catalyst. More pronounced is the influence of the amount of added molar equivalents of H(2)O(2) (20-110 mol % with respect to the substrate). Our present results reflect the complex redox chemistry of the Mn catalyst 1/H(2)O(2)/co-catalyst system in the early phase of the alkene oxidation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aza Compounds / chemistry
  • Catalysis
  • Epoxy Compounds / chemical synthesis*
  • Epoxy Compounds / chemistry
  • Hydrogen Peroxide / chemistry*
  • Manganese / chemistry*
  • Organometallic Compounds / chemistry
  • Oxidation-Reduction
  • Propanols / chemistry*
  • Stereoisomerism

Substances

  • 1,4,7-trimethyl-1,4,7-triazacyclononane
  • Aza Compounds
  • Epoxy Compounds
  • Organometallic Compounds
  • Propanols
  • allyl alcohol
  • Manganese
  • Hydrogen Peroxide