Abstract
3',4'-Di-O-(S)-comphanoyl-(+)-cis-khellactone (DCK) is a synthetic khellactone ester that exhibits potent anti-HIV activity with a mechanism distinct from clinically used anti-HIV agents. Several series of DCK analoges have been synthesized and evaluated for inhibitory effects against HIV. This review article describes recent progress in the discovery, structural modification, and structure-activity relationship studies of potent anti-HIV DCK derivatives.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / pharmacology
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Biological Availability
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Camphor / analogs & derivatives*
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Camphor / chemical synthesis
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Camphor / chemistry
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Camphor / pharmacology
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Coumarins / chemical synthesis
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Coumarins / chemistry*
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Coumarins / pharmacology
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HIV / drug effects
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HIV Reverse Transcriptase / antagonists & inhibitors*
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Humans
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Lactones / chemical synthesis*
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Lactones / chemistry
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Lactones / pharmacology
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Structure-Activity Relationship
Substances
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3'R,4'R-di-O-(-)-camphanoyl-(+)-cis-khellactone
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Anti-HIV Agents
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Coumarins
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Lactones
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Camphor
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HIV Reverse Transcriptase