The relationships between daily life events and the availabilities of serotonin transporters and dopamine transporters in healthy volunteers--a dual-isotope SPECT study

Tzung Lieh Yeh; I Hui Lee; Kao Ching Chen; Po See Chen; Wei Jen Yao; Yeng Kuang Yang; Nan Tsing Chiu; Ru Band Lu

doi:10.1016/j.neuroimage.2008.12.004

The relationships between daily life events and the availabilities of serotonin transporters and dopamine transporters in healthy volunteers--a dual-isotope SPECT study

Neuroimage. 2009 Apr 1;45(2):275-9. doi: 10.1016/j.neuroimage.2008.12.004. Epub 2008 Dec 24.

Authors

Tzung Lieh Yeh¹, I Hui Lee, Kao Ching Chen, Po See Chen, Wei Jen Yao, Yeng Kuang Yang, Nan Tsing Chiu, Ru Band Lu

Affiliation

¹ Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan.

PMID: 19130891
DOI: 10.1016/j.neuroimage.2008.12.004

Abstract

The aim of this study was to examine the relationships between the daily life events and the availabilities of serotonin transporters (SERT) and dopamine transporters (DAT) in healthy volunteers. Thirty-seven volunteers, 19 males and 18 females, were recruited. The SERT availability was approximated using SPECT and [123I] ADAM while the DAT availability was approximated using SPECT and [99mTc] TRODAT-1. All participants completed the Recent Life Change Questionnaire. The results showed that SERT and DAT may be sensitive to the presence of stressful events.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Activities of Daily Living*
Adult
Brain / metabolism*
Dopamine Plasma Membrane Transport Proteins / metabolism*
Female
Humans
Life Change Events*
Male
Middle Aged
Serotonin Plasma Membrane Transport Proteins / metabolism*
Statistics as Topic
Stress, Psychological / diagnostic imaging
Stress, Psychological / metabolism*
Tomography, Emission-Computed, Single-Photon / methods*
Young Adult

Substances

Dopamine Plasma Membrane Transport Proteins
Serotonin Plasma Membrane Transport Proteins