Abstract
A series of xanthone derivatives were synthesized and examined for electrocardiographic, antiarrhythmic, hypotensive and anticonvulsant activities as well as for alpha(1)- and beta(1)-adrenergic binding affinities. Among the investigated compounds, some of them exhibited significant antiarrhythmic and/or hypotensive activity. The data obtained via receptor binding assay are in agreement with pharmacological results and could explain antiarrhythmic and/or hypotensive activity of the newly synthesized structures.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic alpha-1 Receptor Antagonists
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Adrenergic alpha-2 Receptor Antagonists
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Animals
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Anti-Arrhythmia Agents / chemical synthesis
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Anti-Arrhythmia Agents / chemistry
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Anti-Arrhythmia Agents / pharmacology*
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Anticonvulsants / chemistry
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Anticonvulsants / pharmacology*
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Anticonvulsants / toxicity
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Antihypertensive Agents / chemical synthesis
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Antihypertensive Agents / chemistry
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Antihypertensive Agents / pharmacology*
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Electrocardiography
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Kinetics
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Male
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Mice
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Rats
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Rats, Wistar
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Receptors, Adrenergic, alpha-1 / metabolism
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Receptors, Adrenergic, alpha-2 / metabolism
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Seizures / chemically induced
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Xanthones / chemical synthesis
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Xanthones / chemistry
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Xanthones / pharmacology*
Substances
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Adrenergic alpha-1 Receptor Antagonists
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Adrenergic alpha-2 Receptor Antagonists
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Anti-Arrhythmia Agents
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Anticonvulsants
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Antihypertensive Agents
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Receptors, Adrenergic, alpha-1
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Receptors, Adrenergic, alpha-2
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Xanthones