Abstract
Gold nanoparticles functionalized with water-soluble zwitterionic ligands form kinetically stable complexes with hydrophobic drugs and dyes. These drugs and dyes are efficiently released into cells, as demonstrated through fluorescence microscopy and cytotoxicity assays. Significantly, there is little or no cellular uptake of particle, making these low toxicity particles promising for delivery applications.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
Gold / chemistry
-
Humans
-
Hydrophobic and Hydrophilic Interactions*
-
Metal Nanoparticles / chemistry*
-
Metal Nanoparticles / toxicity
-
Metal Nanoparticles / ultrastructure
-
Microscopy, Electron, Transmission
-
Molecular Structure
-
Neoplasms* / pathology
-
Pharmaceutical Preparations / chemistry*
Substances
-
Pharmaceutical Preparations
-
Gold