Abstract
In mammals and humans, reproductive capacity is attained at puberty as the end-point of a complex series of developmental and neuroendocrine events that lead to true sexual maturity. As for humans, sexual precocity looks like a pathologic status. While for some animals, sexual precocity may be a valuable quantitative character. For some species, the character of sexual precocity was developed in the evolutionary process and stably transmitted to future generations. Sexual precocity is a complex character determined by polygenes. This review introduced the association between KiSS-1, GPR54, LHR, FSHR, CYP, ER, TGFa, IGF-, GNAS1, HSD3B2, SHBG, VDR genes and sexual precocity in mammals.
MeSH terms
-
Animals
-
GTP-Binding Protein alpha Subunits, Gs / genetics
-
GTP-Binding Protein alpha Subunits, Gs / metabolism
-
Gene Expression Regulation, Developmental
-
Humans
-
Progesterone Reductase / genetics
-
Progesterone Reductase / metabolism
-
Puberty, Precocious / genetics
-
Puberty, Precocious / metabolism
-
Receptors, Estrogen / genetics
-
Receptors, Estrogen / metabolism
-
Receptors, FSH / genetics
-
Receptors, FSH / metabolism
-
Receptors, G-Protein-Coupled / genetics
-
Receptors, G-Protein-Coupled / metabolism
-
Sexual Maturation / genetics*
-
Transforming Growth Factor alpha / genetics
-
Transforming Growth Factor alpha / metabolism
Substances
-
Receptors, Estrogen
-
Receptors, FSH
-
Receptors, G-Protein-Coupled
-
Transforming Growth Factor alpha
-
3 beta-hydroxysteroid dehydrogenase type II
-
Progesterone Reductase
-
GTP-Binding Protein alpha Subunits, Gs