Abstract
Tailoring steps are often important for the activity of mature antibiotics. Here, we report that novel decarboxylated FR-008/candicidin derivatives were obtained from the P450 monooxygenase gene fscP mutant of Streptomyces sp. strain FR-008. The toxicity of decarboxylated FR-008/candicidin derivatives has been shown to be greatly reduced compared to that of wild-type FR-008/candicidin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / biosynthesis*
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Anti-Bacterial Agents / toxicity
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Candicidin / biosynthesis*
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Candicidin / toxicity
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Erythrocytes / drug effects
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Gene Deletion
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Genes, Bacterial
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Metabolic Networks and Pathways
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Mixed Function Oxygenases / genetics
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Mixed Function Oxygenases / metabolism*
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Molecular Structure
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Rabbits
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Streptomyces / genetics
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Streptomyces / metabolism*
Substances
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Anti-Bacterial Agents
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Candicidin
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Mixed Function Oxygenases