Abstract
Eosinophilic esophagitis is a chronic disease that leads to either persistent symptoms or, at times, intermittent "flares." It shares many features with other atopic diseases (asthma, allergic rhinitis, and atopic dermatitis), including the following: T helper 2 cells and eosinophils play a critical role in the pathogenesis of the disease; avoidance of allergens promotes remission of disease and symptom control; and locally applied corticosteroids provide control. Finally, most patients who have eosinophilic gastrointestinal disorders have an associated atopic disease.
MeSH terms
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Adrenal Cortex Hormones / therapeutic use
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Allergens / immunology
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Animals
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Cell Movement
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Cytokines / metabolism
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Eosinophilia / complications
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Eosinophilia / drug therapy
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Eosinophilia / immunology*
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Eosinophilia / pathology
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Eosinophilia / physiopathology
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Eosinophils / immunology
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Eosinophils / metabolism*
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Eosinophils / pathology
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Esophagitis / complications
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Esophagitis / drug therapy
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Esophagitis / immunology*
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Esophagitis / pathology
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Esophagitis / physiopathology
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Humans
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Hypersensitivity, Immediate / complications
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Hypersensitivity, Immediate / drug therapy
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Hypersensitivity, Immediate / immunology*
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Hypersensitivity, Immediate / pathology
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Hypersensitivity, Immediate / physiopathology
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Mice
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Th2 Cells / immunology
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Th2 Cells / metabolism*
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Th2 Cells / pathology
Substances
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Adrenal Cortex Hormones
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Allergens
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Cytokines