Circadian activity and abundance rhythms of the Neurospora clock transcription factor WCC associated with rapid nucleo-cytoplasmic shuttling

Genes Dev. 2008 Dec 15;22(24):3397-402. doi: 10.1101/gad.507408.

Abstract

The Neurospora clock protein FREQUENCY (FRQ) inhibits its transcriptional activator WHITE COLLAR COMPLEX (WCC) in a negative feedback loop and supports its accumulation in a positive loop. We show that positive feedback is a delayed effect of negative feedback underlying the same post-translational mechanisms: DNA-binding-competent active WCC commits rapidly to degradation. FRQ-dependent phosphorylation of WCC, which interferes with DNA binding (negative feedback), leads to reduced turnover and slow accumulation of newly expressed WCC (positive feedback). When DNA binding of WCC is compromised by mutation, its accumulation is independent of FRQ. Cycles of FRQ-dependent inactivation and PP2A-dependent reactivation of WCC occur in the minute range and are coupled to obligate rapid cycles of nucleo-cytoplasmic shuttling. WCC shuttling and activity cycles are modulated by FRQ in circadian fashion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Nucleus / metabolism*
  • Circadian Rhythm / genetics
  • Circadian Rhythm / physiology
  • Cytoplasm / metabolism*
  • DNA-Binding Proteins / metabolism
  • Feedback, Physiological / physiology
  • Fungal Proteins / metabolism*
  • Gene Expression Regulation, Fungal
  • Neurospora / genetics*
  • Neurospora / metabolism*
  • Protein Transport / physiology
  • Time Factors
  • Transcription Factors / metabolism*

Substances

  • DNA-Binding Proteins
  • Fungal Proteins
  • Transcription Factors
  • white collar 2 protein, Neurospora