High-purity discrete PEG-oligomer crystals allow structural insight

Angew Chem Int Ed Engl. 2009;48(7):1248-52. doi: 10.1002/anie.200804623.

Abstract

To great (monodisperse) lengths: An improved synthesis of purer ethylene glycol (EG) oligomers allows access to 16- and 32-mers pure enough for multiple incorporation, and also to the longest (48-mer) discrete EG oligomer yet reported. The high purity enables the first crystallizations and hence the first glimpses of secondary 3(10)-helical PEG structures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallization
  • Ethylene Glycol / chemical synthesis
  • Ethylene Glycol / chemistry
  • Mass Spectrometry
  • Molecular Structure
  • Polyethylene Glycols / chemical synthesis*
  • Polyethylene Glycols / chemistry*
  • X-Ray Diffraction

Substances

  • Polyethylene Glycols
  • Ethylene Glycol