Sensitization of the thymus to hypoplastic effect of glucocorticoids after long-term hypokinetic stress

V E Tseilikman; T A Filimonova; N V Boyarinova; S V Sibiryak; D A Kozochkin; A I Sinitsky

doi:10.1007/s10517-008-0201-8

Sensitization of the thymus to hypoplastic effect of glucocorticoids after long-term hypokinetic stress

Bull Exp Biol Med. 2008 Jul;146(1):36-7. doi: 10.1007/s10517-008-0201-8.

Authors

V E Tseilikman¹, T A Filimonova, N V Boyarinova, S V Sibiryak, D A Kozochkin, A I Sinitsky

Affiliation

¹ Chelyabinsk State Medical Academy, Russian Ministry of Health, Russia.

PMID: 19145344
DOI: 10.1007/s10517-008-0201-8

Abstract

Long-term hypokinesia increases sensitivity of the thymus to the hypoplastic effect of glucocorticoid preparation triamcinolone acetonide by potentiating the proapoptotic effect of the glucocorticoid.

MeSH terms

Animals
Cell Cycle / drug effects
Female
Glucocorticoids / pharmacology*
Immobilization* / physiology
Immobilization* / psychology
Male
Motor Activity / physiology*
Rats
Rats, Wistar
Restraint, Physical / physiology
Restraint, Physical / psychology
Stress, Psychological*
Thymus Gland / cytology
Thymus Gland / drug effects*
Thymus Gland / metabolism
Triamcinolone / chemistry
Triamcinolone / pharmacology

Substances

Glucocorticoids
Triamcinolone