Abstract
Neonatal (from day 2 to day 7 of life) injection of neuropeptide semax to mice of 5 inbred strains significantly reduced predisposition to audiogenic epilepsy in only one-month-old DBA/2J mice, which manifested in changes in the mean audiogenic sensitivity score and percentage of animals dead as a result of acoustic stimulation.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acoustic Stimulation
-
Adrenocorticotropic Hormone / analogs & derivatives*
-
Adrenocorticotropic Hormone / therapeutic use
-
Animals
-
Animals, Newborn
-
Disease Susceptibility
-
Epilepsy, Reflex / drug therapy*
-
Epilepsy, Reflex / genetics
-
Epilepsy, Reflex / prevention & control*
-
Female
-
Humans
-
Male
-
Mice
-
Mice, Inbred Strains*
-
Neuroprotective Agents / therapeutic use*
-
Peptide Fragments / therapeutic use*
-
Rats
-
Rats, Wistar
Substances
-
Neuroprotective Agents
-
Peptide Fragments
-
ACTH (4-7), Pro-Gly-Pro-
-
Adrenocorticotropic Hormone