Abstract
A series of seven limonene beta-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar range. The activities found for 3b and 3f were about 100-fold more potent than the standard drug, Pentamidine, in the same test, while limonene did not display any activity. This is the first report of antileishmanial activity by limonene beta-amino alcohol derivatives.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Alcohols / chemical synthesis*
-
Amino Alcohols / pharmacology
-
Amino Alcohols / toxicity
-
Animals
-
Antiprotozoal Agents / chemical synthesis*
-
Antiprotozoal Agents / pharmacology
-
Antiprotozoal Agents / toxicity
-
Cyclohexenes / chemistry*
-
Cyclohexenes / pharmacology
-
Cyclohexenes / toxicity
-
Leishmania braziliensis / drug effects*
-
Limonene
-
Mice
-
Molecular Structure
-
Parasitic Sensitivity Tests
-
Structure-Activity Relationship
-
Terpenes / chemistry*
-
Terpenes / pharmacology
-
Terpenes / toxicity
Substances
-
Amino Alcohols
-
Antiprotozoal Agents
-
Cyclohexenes
-
Terpenes
-
Limonene