Abstract
The hallmark of HIV-1/simian immunodeficiency virus infections is the progressive depletion of CD4(+) T cells that ultimately renders the host incapable of defending against AIDS-defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4(+) T-cell loss, this review focuses on the growing evidence that collagen deposition and consequent fibrotic damage to the lymphatic tissue T-cell compartment contributes to CD4(+) T-cell decline and limits CD4(+) T-cell repopulation, even with highly active antiretroviral therapy.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Adult
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Animals
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Antiretroviral Therapy, Highly Active
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CD4-Positive T-Lymphocytes / immunology*
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CD4-Positive T-Lymphocytes / pathology
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Child
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Collagen / metabolism*
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Fibrosis / immunology
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Fibrosis / pathology
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Fibrosis / virology
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HIV Infections* / drug therapy
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HIV Infections* / immunology
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HIV Infections* / virology
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HIV-1 / pathogenicity*
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Humans
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Immune Reconstitution Inflammatory Syndrome
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Lymphoid Tissue* / immunology
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Lymphoid Tissue* / metabolism
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Lymphoid Tissue* / pathology
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Lymphoid Tissue* / virology
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Simian Acquired Immunodeficiency Syndrome* / drug therapy
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Simian Acquired Immunodeficiency Syndrome* / immunology
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Simian Acquired Immunodeficiency Syndrome* / virology
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Simian Immunodeficiency Virus / pathogenicity*
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T-Lymphocytes / immunology
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T-Lymphocytes / pathology