The use of Cyan Fluorescent Protein variants with a distinctive lifetime signature

Mol Biosyst. 2009 Feb;5(2):151-3. doi: 10.1039/b815445g. Epub 2008 Dec 5.

Abstract

The use of Cyan Fluorescent Proteins, with a distinctive lifetime signature, opens up new alternatives to track and semi-quantify the relative expression of proteins in vivo using a single excitation source and emission channel.

MeSH terms

  • Animals
  • Cricetinae
  • Directed Molecular Evolution
  • Genetic Techniques*
  • Green Fluorescent Proteins / metabolism*
  • HeLa Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Microscopy, Fluorescence / instrumentation*
  • Microscopy, Fluorescence / methods*
  • Mutation
  • Protein Engineering / methods
  • Temperature
  • Time Factors

Substances

  • Cyan Fluorescent Protein
  • Green Fluorescent Proteins