Abstract
Copper-catalyzed coupling of imines, vinylstannanes, or alkynes and o-bromoaroyl chlorides followed by Pd(0)-catalyzed annulations afforded indenoisoquinolines. Protocols requiring minimal purifications were developed, providing new methods for the construction of combinatorial libraries.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Alkynes / chemistry*
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Catalysis
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Combinatorial Chemistry Techniques
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Copper / chemistry*
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Hydrocarbons, Halogenated / chemistry*
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Imines / chemistry*
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Indenes / chemical synthesis*
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Indenes / chemistry
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Isoquinolines / chemical synthesis*
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Isoquinolines / chemistry
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Molecular Structure
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Palladium / chemistry
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Tin Compounds / chemistry*
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Vinyl Compounds / chemistry*
Substances
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Alkynes
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Hydrocarbons, Halogenated
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Imines
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Indenes
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Isoquinolines
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Tin Compounds
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Vinyl Compounds
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stannane
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Palladium
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Copper