Abstract
We present biological imaging and sensing methods based on optical resonance and interference. In fluorescence microscopy, our nanoscale imaging capability sheds light onto conformational changes of DNA, DNA-protein complexes and polymer coatings on a solid surface. Interference measurements on a layered substrate yield a label-free sensing platform for protein binding in a high-throughput micro-array format.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biosensing Techniques
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Electrochemistry / instrumentation
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Fluorescence
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Fluorescent Dyes
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Humans
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Microscopy, Fluorescence / instrumentation*
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Microscopy, Fluorescence / methods*
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Nucleic Acid Hybridization
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Optics and Photonics / instrumentation*
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Optics and Photonics / methods*
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Protein Array Analysis / instrumentation*
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Protein Array Analysis / methods*
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Proteins / chemistry*
Substances
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Fluorescent Dyes
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Proteins