[Study on biligustilides from Angelica sinensis]

Zhongguo Zhong Yao Za Zhi. 2008 Oct;33(19):2196-201.
[Article in Chinese]

Abstract

Objective: To study the chemical constituents of Angelica sinensis.

Method: The constituents were separated by chromatographic methods, and their structures were identified on the basis of spectroscopic analysis.

Result: Eight compounds were isolated and identified as levistolide A (1), senkyunolide O (2), (3Z, 3Z')-6.8', 7.3'-diligustilide (3), tokinolide B (4), isotokinolide B (5), (3'Z)-(3R, 8S, 3a'R, 6'S)-3, 3a': 8, 6'-biligustilide (6), E, E'-3. 3', 8. 8'-diligustilide (7) and E, E'-3. 3', 8. 8'-isodiligustilide (8), which are all diligustilides.

Conclusion: Compound 7 was obtained from the plant for the first time; compounds 6 and 8 are new compounds.

MeSH terms

  • Angelica sinensis / chemistry*
  • Benzofurans / chemistry
  • Drugs, Chinese Herbal / chemistry*
  • Molecular Structure

Substances

  • Benzofurans
  • Drugs, Chinese Herbal
  • levistolide A
  • 3-N-butyl-4,5-dihydrophthalide