Abstract
A new anthraquinone, Rubiacordone A (1) (6-acetoxy-1-hydroxy-2-methylanthraquinone-3-O-alpha-L-rhamnopyranoside), was isolated together with the known anthraquinone, 1-acetoxy-6-hydroxy-2-methylanthraquinone-3-O-[alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside] (2), from the dried roots of Rubia cordifolia. Their structures were elucidated on the basis of extensive 1D and 2D-NMR, as well as HRESI-MS spectroscopic analysis. Metabolites 1 and 2 showed considerable antimicrobial activity against Gram-positive bacteria.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthraquinones* / chemistry
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Anthraquinones* / isolation & purification
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology
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Drugs, Chinese Herbal / chemistry
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Glycosides* / chemistry
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Glycosides* / isolation & purification
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Gram-Positive Bacteria / drug effects
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Humans
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Medicine, Chinese Traditional
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Extracts / chemistry*
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Plant Roots / chemistry*
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Rubia / chemistry*
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Spectrometry, Mass, Electrospray Ionization
Substances
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Anthraquinones
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Anti-Infective Agents
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Drugs, Chinese Herbal
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Glycosides
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Plant Extracts