Abstract
We report a case of accelerated metabolism of voriconazole during therapy for invasive pulmonary aspergillosis, resulting in subtherapeutic levels. Target voriconazole levels were restored with high dosages of voriconazole (up to 40 mg/kg of body weight/day) and the addition of cimetidine as a cytochrome P450 enzyme inhibitor.
Publication types
-
Case Reports
-
Research Support, N.I.H., Intramural
MeSH terms
-
Antifungal Agents / metabolism*
-
Cimetidine / pharmacology*
-
Cytochrome P-450 CYP3A / biosynthesis
-
Drug Interactions
-
Hemofiltration
-
Humans
-
Male
-
Middle Aged
-
Pyrimidines / metabolism*
-
Triazoles / metabolism*
-
Voriconazole
Substances
-
Antifungal Agents
-
Pyrimidines
-
Triazoles
-
Cimetidine
-
Cytochrome P-450 CYP3A
-
CYP3A4 protein, human
-
Voriconazole