A new artificial beta-sheet that dimerizes through parallel beta-sheet interactions

Org Lett. 2009 Feb 19;11(4):1003-6. doi: 10.1021/ol802993v.

Abstract

This paper introduces a chemical model of a beta-sheet that dimerizes through parallel beta-sheet interactions in CDCl(3) solution. The model consists of two C-terminally linked dipeptides connected to a molecular template. (1)H NMR studies establish the beta-sheet folding and dimerization of the model system. This system corroborates that linking two peptide strands and blocking one edge of the assembly creates soluble, easy-to-study systems that participate in the types of interactions that occur widely in peptide and protein aggregates.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Models, Chemical*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Protein Structure, Secondary
  • Proteins / chemistry*

Substances

  • Proteins