Abstract
Abstract While infection with HIV-1 has become a pandemic, the presence of HIV-2 is also of concern in certain regions of the world. We have characterized the gp105 region of the envelope gene of HIV-2 isolates from Western India. Phylogenetic analysis of all 18 sequences revealed that these sequences were closely related to each other as well as to published African and European HIV-2 group A sequences, with an overall genetic divergence of 10.9% (range 2-14%). Our study sequences showed close relatedness with West African HIV-2 group A (CAM group) sequences from Guinea Bissau with 89% homology. This was further confirmed by SimPlot as well as RIP analysis. Accordingly, the sequences presented here demonstrate the predominance of HIV-2 group A infection and show no evidence of HIV-2 recombination in Western India.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Cluster Analysis
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Female
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HIV Infections / virology*
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HIV-2 / classification*
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HIV-2 / genetics
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HIV-2 / isolation & purification*
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Humans
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India
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Male
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Middle Aged
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Molecular Sequence Data
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Phylogeny
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Sequence Analysis, DNA
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Sequence Homology
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env Gene Products, Human Immunodeficiency Virus / genetics*
Substances
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env Gene Products, Human Immunodeficiency Virus
Associated data
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GENBANK/DQ870430
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GENBANK/DQ870431
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GENBANK/DQ870432
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