Abstract
Drug-resistant bacteria are becoming more prevalent both in the community and in hospitals. In a search for new antibiotic leads, we used a high-throughput natural products chemistry approach to isolate one new (1) and two known (2, 3) dammarane-type triterpenes with mass-limited material from the African plant Oncoba manii. The new compound was determined by spectroscopic methods to be 1beta,2alpha,3beta,20(R)-tetrahydroxydammar-24-ene 3-O-alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyranoside. Compounds 1 and 2 inhibited the growth of methicillin-resistant Staphylococcus aureus (MRSA).
MeSH terms
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Dammaranes
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Disaccharides / isolation & purification
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Disaccharides / pharmacology
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Glycosides / isolation & purification
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Glycosides / pharmacology
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Salicaceae / chemistry*
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
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Vancomycin / pharmacology
Substances
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1beta,2alpha,3beta,20(R)-tetrahydroxydammar-24-ene 3-O-alpha-L-rhamnopyranosyl-(1-2)-beta-D-glucopyranoside
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Anti-Bacterial Agents
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Disaccharides
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Glycosides
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Plant Extracts
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Triterpenes
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Vancomycin