Abstract
During a 6-month period, 37/513 (7.2%) Pseudomonas aeruginosa isolates belonging to 13 pulsed-field gel electrophoresis (PFGE) groups from Puerto Rican hospitals were carbapenem nonsusceptible. Seven of 37 isolates from four PFGE groups carried bla(IMP-18), and 25/37 isolates from seven PFGE groups carried bla(KPC). The results indicated the clonal spread of bla(KPC)-positive P. aeruginosa isolates into several Puerto Rican hospitals and the dissemination of bla(IMP-18) and bla(KPC) into genetically unrelated isolates.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Bacterial Outer Membrane Proteins / physiology
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Carbapenems / pharmacology*
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Child
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Child, Preschool
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Drug Resistance, Bacterial
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Electrophoresis, Gel, Pulsed-Field
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Female
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Humans
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Infant
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Male
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Membrane Transport Proteins / physiology
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Microbial Sensitivity Tests
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Middle Aged
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Polymerase Chain Reaction
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Porins / physiology
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / enzymology
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Pseudomonas aeruginosa / genetics
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beta-Lactamases / genetics
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beta-Lactamases / physiology*
Substances
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Bacterial Outer Membrane Proteins
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Carbapenems
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Membrane Transport Proteins
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MexA protein, Pseudomonas aeruginosa
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Porins
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OprD protein, Pseudomonas aeruginosa
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beta-lactamase KPC-1
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beta-Lactamases
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beta-lactamase IMP-18, Pseudomonas aeruginosa