Acrebol, a novel toxic peptaibol produced by an Acremonium exuviarum indoor isolate

J Appl Microbiol. 2009 Mar;106(3):909-23. doi: 10.1111/j.1365-2672.2008.04062.x. Epub 2009 Jan 21.

Abstract

Aims: To identify a toxin and its producer isolated from woody material in a building where the occupants experienced serious ill health symptoms.

Methods and results: Hyphal extracts of an indoor fungus, identified as the cycloheximide-tolerant species Acremonium exuviarum, inhibited motility of boar spermatozoa (EC(50) 5 +/- 2 microg of crude solids ml(-1)) and caused cytolysis of murine neuroblastoma cells (MNA) and feline fetal lung cells (FL). The responsible substances were purified and identified as two structurally similar, heat-stable, novel, toxic peptaibols, 1726 Da and 1740 Da, respectively, with amino acid sequences of Acetyl-Phe-Iva/Val-Gln-Aib-Ile-Thr-Leu-Aib-Pro-Aib-Gln-Pro-Aib-(X-X-X)-SerOH and Acetyl-Phe-Iva/Val-Gln-Aib-Ile-Thr-Leu-Val-Pro-Aib-Gln-Pro-Aib-(X-X-X)-SerOH. Purified acrebol inhibited motility of boar sperm, depleted ATP half-content in 1 day (EC(50) of 0.1 microg ml(-1), 60 nmol l(-1)) depolarised the mitochondria after 2 days, but did not affect the cellular content in NADH. This indicates mitochondrial toxicity. Plate-grown biomass of A. exuviarum BMB4 contained 0.1-1% (w/w) of acrebol, depending on the culture medium.

Conclusions: Acrebol paralysed the energy generation of mammalian cells suggesting that mitochondria were its target of action.

Significance and impact of the study: Acremonium exuviarum, as an indoor fungus, is potentially hazardous to health because of the toxic peptaibols that it produces.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acremonium / chemistry*
  • Acremonium / metabolism
  • Amino Acid Sequence
  • Animals
  • Apoptosis / drug effects
  • Bacterial Toxins / toxicity
  • Cats
  • Chromatography, High Pressure Liquid
  • Housing
  • Lung / drug effects
  • Lung / pathology
  • Male
  • Mass Spectrometry
  • Molecular Weight
  • Neuroblastoma / pathology
  • Peptaibols / chemistry*
  • Peptaibols / pharmacology
  • Rats
  • Spermatozoa / drug effects
  • Wood / microbiology

Substances

  • Bacterial Toxins
  • Peptaibols