Objective: To study the protein expression of adenylate kinases (AK)-2 in the brain tissues of patients with drug-refractory temporal epilepsy and the clinical value thereof.
Methods: Specimens of brain from 40 patients with refractory temporal epilepsy, and 20 sex- and age-matched persons with brain trauma. Immunohistochemistry and immunofluorescence examination were used to test the levels of AK2.
Results: AK2 was expressed in the temporal lobes and hippocampuses of all epileptics, mainly in the cell bodies, and not in the brain tissues of the controls.
Conclusion: The overexpression of AK2 may be involved in the pathogenesis of drug-refractory epilepsy and become an important symbol thereof.