Abstract
The authors prospectively followed patients with treatment-resistant obsessive-compulsive disorder (OCD). Between 1988 and 1995, 56 patients with a history of inadequate response to oral clomipramine received 14 infusions of intravenous clomipramine. The follow-up period ranged from 4 to 11 years after treatment. Of the 44 subjects interviewed at follow-up, 70.5% had current OCD and 29.5% had sub-threshold OCD. Almost half reported feeling much improved or very much improved compared to their state prior to treatment with intravenous clomipramine.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Antidepressive Agents, Tricyclic / administration & dosage
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Antidepressive Agents, Tricyclic / therapeutic use
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Clomipramine / administration & dosage
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Clomipramine / therapeutic use
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Drug Resistance
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Female
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Follow-Up Studies
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Humans
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Injections, Intravenous
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Interview, Psychological
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Male
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Mental Disorders / complications
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Mental Disorders / psychology
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Middle Aged
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Obsessive-Compulsive Disorder / drug therapy*
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Obsessive-Compulsive Disorder / psychology*
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Psychiatric Status Rating Scales
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Quality of Life
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Surveys and Questionnaires
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Young Adult
Substances
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Antidepressive Agents, Tricyclic
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Clomipramine