Abstract
Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / biosynthesis*
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antibiotics, Antineoplastic / pharmacology
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Benzoxazoles / isolation & purification
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Benzoxazoles / metabolism
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Benzoxazoles / pharmacology*
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Cell Line, Tumor
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Cell Survival
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Drug Evaluation, Preclinical
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Drug Screening Assays, Antitumor
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Fermentation
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Gram-Positive Bacteria / drug effects
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Humans
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Models, Molecular
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Molecular Conformation
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Seawater / microbiology
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Streptomyces / chemistry
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Streptomyces / metabolism*
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Water Microbiology
Substances
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Anti-Bacterial Agents
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Antibiotics, Antineoplastic
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Benzoxazoles
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caboxamycin