Abstract
Recent evidence suggests that antiglucocorticoids, like conventional antidepressants, may recover depressive symptoms by boosting hippocampal neurogenesis. Here, we explore several possible antiglucocorticoid-based antidepressive therapeutic strategies. Firstly, we review specific glucocorticoid receptor/antagonist interactions. Secondly, we discuss a potential new therapeutic target, doublecortin-like kinase, which regulates glucocorticoid signaling in neuronal progenitor cells.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antidepressive Agents / pharmacology*
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Depression / drug therapy*
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Depression / metabolism*
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Glucocorticoids / antagonists & inhibitors*
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Humans
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Hypothalamo-Hypophyseal System / physiology
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Models, Molecular
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Nerve Tissue / growth & development*
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Receptors, Glucocorticoid / antagonists & inhibitors
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Stress, Psychological / complications
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Stress, Psychological / metabolism
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Stress, Psychological / psychology
Substances
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Antidepressive Agents
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Glucocorticoids
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Receptors, Glucocorticoid