3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1434-7. doi: 10.1016/j.bmcl.2009.01.027. Epub 2009 Jan 15.

Abstract

A series of potent and selective 3,4-diamino-1,2,5-thiadiazoles were prepared and found to show excellent binding affinities towards CXCR2 receptor.

Publication types

  • Comparative Study

MeSH terms

  • Diamines / chemical synthesis*
  • Diamines / pharmacology
  • Humans
  • Protein Binding
  • Receptors, Interleukin-8B / antagonists & inhibitors*
  • Receptors, Interleukin-8B / metabolism
  • Structure-Activity Relationship
  • Thiadiazoles / chemical synthesis*
  • Thiadiazoles / pharmacology

Substances

  • Diamines
  • Receptors, Interleukin-8B
  • Thiadiazoles