Abstract
Although complex hallucinations are extremely vivid, painful symptoms in schizophrenia, little is known about the underlying mechanisms of multisensory integration in such a phenomenon. We investigated the neural basis of these altered states of consciousness in a patient with schizophrenia, by combining state of the art neuroscientific exploratory methods like functional MRI, diffusion tensor imaging, cortical thickness analysis, electrical source reconstruction and trans-cranial magnetic stimulation. The results shed light on the functional architecture of the hallucinatory processes, in which unimodal information from different modalities is strongly functionally connected to higher-order integrative areas.
MeSH terms
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Adult
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Algorithms
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Atrophy
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Brain Mapping / methods
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Cerebral Cortex / pathology
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Cerebral Cortex / physiopathology*
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Consciousness / physiology*
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Diffusion Magnetic Resonance Imaging / methods
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Dominance, Cerebral / physiology
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Electroencephalography / methods
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Frontal Lobe / physiopathology
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Gyrus Cinguli / physiopathology
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Hallucinations / physiopathology*
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Humans
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Image Processing, Computer-Assisted / methods
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Imaging, Three-Dimensional
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Magnetic Resonance Imaging / methods
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Male
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Nerve Net / physiopathology
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Neurons / physiology
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Occipital Lobe / physiopathology
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Organ Size / physiology
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Perception / physiology*
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Psychiatric Status Rating Scales
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Schizophrenia, Paranoid / physiopathology*
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Schizophrenia, Paranoid / psychology
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Signal Processing, Computer-Assisted
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Software
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Temporal Lobe / physiopathology
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Transcranial Magnetic Stimulation / methods