Abstract
A cunning and dangerous plan foiled! An enzyme-specific molecular construct exploits the overexpression of beta-lactamase in several drug-resistant bacteria. Specific photodynamic toxicity was detected towards beta-lactam-resistant methicillin-resistant Staphylococcus aureus (MRSA), whereby the usual mechanism for antibiotic resistance (cleavage of the beta-lactam ring) releases the phototoxic component from the prodrug (see picture; Q = quencher).
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Kinetics
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Methicillin-Resistant Staphylococcus aureus / metabolism
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Methicillin-Resistant Staphylococcus aureus / radiation effects*
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Microbial Sensitivity Tests
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Photochemotherapy
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / pharmacology
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Prodrugs / chemistry
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Prodrugs / pharmacology
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beta-Lactamases / metabolism
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beta-Lactamases / radiation effects*
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beta-Lactamases / toxicity
Substances
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Photosensitizing Agents
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Prodrugs
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beta-Lactamases